Several organizations have issued guidelines for safe syringe use. For example, the World Health Organization (WHO) and UNICEF have been promoting the use of single-use syringes and safety boxes. This policy is important to ensure that vaccines are safe and effective.
Using a safety vaccine syringe helps to reduce the risk of needlestick injury. A safety vaccine syringe is specially designed for vaccine injection. It has a plunger that is easy to read and allows for easy detachment from the needle barrel. The plunger has accurate scale markings that prevent reusing.

In addition to a safety vaccine syringe, it is also important to follow the manufacturer's recommendations when preparing vaccines. For example, it is recommended that vaccines be stored in an area that is separate from other medical equipment. This prevents contamination from other materials. It is also important to avoid injecting vaccine into subcutaneous tissue. It is also important to avoid injecting into nerves, blood vessels, and underlying bone.

Vaccines with adjuvants can also be harmful if injected into these areas. For example, they may cause inflammation and granulomas. This can make them less effective. In addition, a large number of vaccines are administered through an intramuscular (IM) route. For this reason, it is important to select the appropriate needle length based on the client's muscle mass.

It is important to store unused prefilled syringes in a sharps container. If they are not used within a day, they should be discarded.